An insecure but courageous and intelligent teen named Peter Parker, a new student of Horizon High, is bitten by a radioactive spider and given powers. He becomes a hero named Spider-Man after the death of his uncle and he must adapt to this new way of life.

Peter is accepted into Horizon High, a school of geniuses, where his best friend Harry Osborn was suspended; Peter makes his debut as Spider-Man and must fight the Vulture.

The Scorpion is wreaking havoc at the museum and it is up to Spider-Man to stop him.

Norman Osborn creates the Osborn Academy for Geniuses as a way of saving his son Harry the embarrassment of being suspended from Horizon High.

As Peter tries to get through his normal life, he contends with Black Cat to recover the item she stole from Horizon High.

Harry returns to Horizon High, and Max decides to throw the first ever dance party. During the party, the Rhino is born and causes havoc for the students.

Spider-Man meets Sandman and helps him reunite with his estranged daughter with some assistance from the Venom symbiote.

Spider-Man uses his new black costume but it wants to destroy him.

Ghost hijacks the Stark Expo and Spider-Man must unleash the symbiote to save lives.

Miles Morales is bitten by an experimental spider and gains spider powers, so Spider-Man teaches him the responsibilities of being a superhero.

Kraven the Hunter does a live broadcast of his hunt for Spider-Man.

On Halloween night, Spider-Man must team up with the incredible Hulk to stop Man-Wolf, a super-strong gamma-powered werewolf, from infecting the rest of Manhattan.

Spidey must stop a low-level villain who has acquired some impressive freezing technology.

The symbiote has escaped the Avengers Compound and attached itself to a new host. Now Spidey must find out how to beat it and who the new person is underneath.

Spider-Man is targeted by a new costumed figure named Screwball for a series of online prank videos which block him from fighting crime.

When Otto Octavius is caught in an explosion that fuses his robot arms to his body, Spider-Man sees the opportunity to recruit "The Octopus" into becoming a hero.

Spidey invites The Octopus to patrol the streets alongside Miles and himself until it becomes clear that Otto isn't exactly a team player.

Peter spends a day at Oz Academy in the hopes of finding a clue that will convince Harry that his Dad is out to destroy Spider-Man.

Spider-Man must team up with Gwen Stacy and a reluctant Harry Osborn to investigate the truth behind the missing Raymond Warren aka the Jackal.

Spider-Man tracks a new villain with spider powers who steals his experimental stealth suit and threatens the entire city.

Everyone in Manhattan manifests spider powers; Spider-Man and Spider-Gwen must help Black Widow track down Crossbones before he delivers the vibranium to Arnim Zola and Hydra.

Peter must find a way to cure Gwen Stacy and Norman Osborn after they turn into spider monsters; things get harder when Kraven the Hunter turns New York into his hunting grounds.

Peter and Harry must battle through an island of spider monsters to get to Norman Osborn, who appears to control them all; the boys discover the real mastermind.

To cure the spider-monster population of Manhattan, Spider-Man must lead Kid Arachnid, Anya and Harry on a desperate, last-ditch effort to stop the Jackal.

Spider-Man takes on Doc Ock and his Sinister Five before they brainwash Spidey and destroy New York City.

Spider-Man must find a way to stop Hobgoblin, who seems completely bent on doing whatever it takes to destroy Spider-Man.

Peter Parker struggles to balance the best summer vacation ever and his responsibilities as Spider-Man.

Spider-Man is excited to start his second year as a superhero and as a student at Horizon High but discovers that Doc Ock also claims to want a second chance. Can Otto be trusted?

Spider-man's popularity nose dives, thanks to Pete's pictures in the Daily Bugle. Spidey battles a female 'Doc Ock' as the real plan of Dr Octopus is revealed.

Spider-Man tangles with the Wakeriders, a thrill seeking group using Vulture technology.

Spidey teams up with Ms Marvel to investigate a strange school.

Pete becomes weary of supplying footage to Jameson that is used to trash Spider-man's reputation. In a bid to scoop Pete, Eddie Brock tries to photograph substance V-252 and Venom is born.

Venom goes after Peter Parker's family and friends and threatens to expose his secret identity.

A Mystery Villain puts a bounty on Spider-Man's head, bringing on attacks from Panda-Mania, Hippo and Overdrive.

Anya must step-up and embrace being the Spider-Girl; Spider-Man is lured into the Mysterious funhouse and learns that there is a bounty on his head.

Spider-Man faces off against his most bizarre bad guy yet, Jack O' Lantern. Then he turns Prowler, a reluctant villain, to the side of heroes when he helps him save his brother.

Spidey tracks the identity of the mysterious boss that put a price on his head and who has been sending villains after him.

Spider-Man and Miles Morales discover Doc Ock, whose mind has been hiding inside the metal body of The Living Brain, has been behind the mysterious bounty for Spider-Man's head.

Spider-Man must fight his way through the Super-Villain Holding Facility to challenge The Living Brain, the robot body that is housing the mind of Doctor Octopus.

The Bloodgem accidentally reawakens Gwen Stacy's dormant spider-powers, turning her into Ghost Spider!

Doc Ock, now in Spider-Man's body, intends to bring New York City to its knees, but instead finds his newly acquired brain still contains some of Peter Parker's memories.

Doc Ock must adjust to his new life as a hero and is tested by rising crime boss Sand Girl.

Superior Spider-Man is confronted by the Avengers, who suspect that he is not who he claims to be.

When a new criminal duo, Cloak and Dagger, emerge at Midtown High with the plan to take revenge against Midtown’s benefactor Tiberius Stone and his company Alchemax, Superior Spider-Man must take them down and protect the school.

Superior Spider-Man must face his most challenging opponent yet when Venom escapes from stasis and attacks Midtown High.

When a series of attacks by a suspected team of super-villains captures The Avengers, Spider-Man is left to figure out who could be behind it.

Spider-Man takes his mission to The Cellar where he believes The Regent is using the powers of Cloak and Dagger, as well as other supervillains, to hold The Avengers captive.

Spider-Man must take down the slick new villain, Slyde, as he steals various chemicals from around the city in an effort to create a deadly virus that could wipe out New York.

Spider-Man teams up with Spider-Girl, Ghost-Spider and Doc Ock to track down a new threat - the mysterious Goblin Nation.

Spider-Man and Harry Osborn seek the Goblin King to determine who is behind the Goblin Mask.

In order for Spider-Man to defeat the Goblin King, he must first bring together Doc Ock, Spider-Girl, Ghost-Spider, Miles Morales and Harry Osborn.

The assembled Spider Team (Spider-Man, Miles, Ghost-Spider, Hobgoblin, Spider-Girl, and Doctor Octopus) must stop the Goblin King, now armed with a Goblin Mech Suit, before he destroys New York.

When Spider-Man discovers Max Modell is experimenting with a synthetic version of the Venom symbiote, he warns him of the dangers. When Curt Connors stumbles on the experiment, he accidentally releases the real symbiote.

Toddler Groot brings an urgent warning to Spider-Man who has to decode the message and keep Groot out of the hands of A.I.M.

When the symbiotes attack New York City, Spider-Man must convince Mark Spector to come out of retirement and help protect the city.

Spider-Man's friend is turned back into Rhino by Swarm. Spidey is forced to fight in the Underground Monster Club.

Discovering a vial of the Jackal formula at Horizon High, the Spider Team realizes that the Jackal has returned since the Spider Island crisis. Spider-Man and Ghost-Spider track down Jackal's secret lab in an attempt to thwart the villain's latest evil plans.

When Spider-Man and his allies attempt to track down the missing and dangerous Lizard, they discover that Venom has returned to seek revenge on the earth.