London 1891. As the police investigate a series of gruesome murders, renowned explorer Sir Malcolm Murray and the strangely beautiful Vanessa Ives know there's something darker at play. In search of someone close to them who has been lost, they recruit American sharp-shooter Ethan Chandler and Dr. Victor Frankenstein to help them on their journey.

In pursuit of answers, Vanessa and Sir Malcolm attend a party at Egyptologist Sir Ferdinand Lyle's home where they encounter the mysteriously beautiful Dorian Gray. The party takes a turn, however, when renowned medium Madame Kali hosts a séance. Meanwhile, Ethan befriends Ms. Brona Croft, a young Irish immigrant

Dr. Frankenstein is confronted by the consequences of his past. Vanessa has a vision of Mina, which leads her, Sir Malcolm, Ethan and Sembene to a strange discovery at the London Zoo.

Vanessa's infatuation with Dorian Gray continues to grow. Professor Abraham Van Helsing is hired to work with Dr. Frankenstein. And Fenton draws his master to Sir Malcolm's mansion.

Vanessa recalls her past and the events that ultimately lead to Mina's disappearance.

Vanessa's latest vision leads Sir Malcolm, Ethan and Sembene to explore a plague ship in search of Mina. Meanwhile, Van Helsing reveals to Dr. Frankenstein more details about the creature that has taken Mina. Later, Vanessa's night with Dorian unlocks something dark within her.

Sir Malcolm, Ethan and Sembene must deal with the aftermath of Vanessa's night of passion with Dorian, when she is possessed by the demon that haunts them... and who has ties to the Master who controls Mina.

After a vision of the Grand Guignol, Vanessa, Sir Malcolm, Ethan, Dr. Frankenstein and Sembene explore an empty theater - only to be confronted by their worst nightmares.